Quick Answer: The most effective caching strategies for Next.js websites at scale combine multi-layer caching, aggressive static generation where possible, and precise cache invalidation. In practice, that means using CDN edge caching for public pages, Incremental Static Regeneration or selective static rendering for content that changes infrequently, and server-side/data caching for personalized or dynamic requests.
At scale, Next.js caching should be designed as a layered system rather than a single mechanism. The highest-leverage approach is to push cacheable content as far toward the edge as possible with CDN caching and static generation, while reserving server-side rendering for truly dynamic or user-specific content. Next.js supports this through features like SSG, ISR, route and fetch caching, and fine-grained revalidation, which together reduce origin load, improve TTFB, and stabilize performance under traffic spikes. The critical operational requirement is invalidation discipline: cache everything that can be safely cached, then use tag-based or time-based revalidation to keep content fresh without sacrificing throughput.