Quick Answer: Minimizing TTFB in a Next.js deployment starts with reducing server work, moving as much content as possible to static generation or edge caching, and eliminating slow origin dependencies from the request path. In practice, the highest-impact fixes are using CDN-backed caching, streaming and partial rendering where appropriate, optimizing serverless or edge function cold starts, and aggressively simplifying backend calls before the first byte is sent.
The fastest Next.js deployments are engineered so the initial request can be fulfilled with minimal compute, minimal blocking I/O, and maximum cache reuse. That means preferring static rendering for stable pages, using ISR or cached RSC responses for frequently requested content, deploying to an edge network close to users, and ensuring any server-side logic is intentionally lightweight. TTFB also improves significantly when you remove waterfall dependencies in data fetching, cache API/database results, preconnect to critical origins, compress responses, and instrument real-user performance so bottlenecks are identified by route, region, and runtime rather than guessed at globally.